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Ginkgo biloba L. 1

Ginkgo bilobaextract 1

Ginkgolide B 1

Yintai 1

acute ischemic stroke 1

bionic synthesis 1

control effect 1

ginkgol 1

network model 1

neuroprotection 1

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Neuroprotective effects of Ginkgo biloba extract and Ginkgolide B against oxygen–glucose deprivation/

Xiaohan Yang, Tiezheng Zheng, Hao Hong, Nan Cai, Xiaofeng Zhou, Changkai Sun, Liying Wu, Shuhong Liu, Yongqi Zhao, Lingling Zhu, Ming Fan, Xuezhong Zhou, Fengxie Jin

Frontiers of Medicine 2018, Volume 12, Issue 3,   Pages 307-318 doi: 10.1007/s11684-017-0547-2

Abstract:

Acute ischemic stroke (AIS), as the third leading cause of death worldwide, is characterized by its high incidence, mortality rate, high incurred disability rate, and frequent reoccurrence. The neuroprotective effects of extract (GBE) against several cerebral diseases have been reported in previous studies, but the underlying mechanisms of action are still unclear. Using a novel rat cortical capillary endothelial cell-astrocyte-neuron network model, we investigated the neuroprotective effects of GBE and one of its important constituents, Ginkgolide B (GB), against oxygen–glucose deprivation/reoxygenation and glucose (OGD/R) injury. In this model, rat cortical capillary endothelial cells, astrocytes, and neurons were cocultured so that they could be synchronously observed in the same system. Pretreatment with GBE or GB increased the neuron cell viability, ameliorated cell injury, and inhibited the cell apoptotic rate through Bax and Bcl-2 expression regulation after OGD/R injury. Furthermore, GBE or GB pretreatment enhanced the transendothelial electrical resistance of capillary endothelial monolayers, reduced the endothelial permeability coefficients for sodium fluorescein (Na-F), and increased the expression levels of tight junction proteins, namely, ZO-1 and occludin, in endothelial cells. Results demonstrated the preventive effects of GBE on neuronal cell death and enhancement of the function of brain capillary endothelial monolayers after OGD/R injury ; thus, GBE could be used as an effective neuroprotective agent for AIS/reperfusion, with GB as one of its significant constituents.

Keywords： acute ischemic stroke     Ginkgo bilobaextract     Ginkgolide B     network model     neuroprotection    

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Research on Bionic Fungicide Yintai and Its Application

Meng Zhaoli,Fang Xiangyang,Luo Lan,Shang Jian

Strategic Study of CAE 2007, Volume 9, Issue 3,   Pages 28-34

Abstract: bionic fungicides synthesized by simulating the lead compound of ginkgol isolated from the exosperm of ginkgofruit. 8.3-time diluted solution of alcohol crude extract from the ginkgo fruit showed 100% inhibtionBoth 200-time and400time solutions of ginkgol, extracted from external seed coat of ginkgo, had 100%

Keywords： Ginkgo biloba L.     ginkgol     bionic synthesis     Yintai     control effect    

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Title Author Date Type Operation

Neuroprotective effects of Ginkgo biloba extract and Ginkgolide B against oxygen–glucose deprivation/

Xiaohan Yang, Tiezheng Zheng, Hao Hong, Nan Cai, Xiaofeng Zhou, Changkai Sun, Liying Wu, Shuhong Liu, Yongqi Zhao, Lingling Zhu, Ming Fan, Xuezhong Zhou, Fengxie Jin

Journal Article

Research on Bionic Fungicide Yintai and Its Application

Meng Zhaoli,Fang Xiangyang,Luo Lan,Shang Jian

Journal Article